Peyronie’s disease is of unknown etiology and is characterized by focal asymmetric fibrosis induration of the shaft of the penis without significant change of the overlying skin.
Fibrosis results in curvature and discomfort of the penis at the time of erection.
It occurs in a young or middle aged man.
Rarely, it may be inherited with an autosomal dominant transmission.
Microscopically, dense dermal fibrosis focally replaces the muscle in the septum of the corpus cavernosum. Occasionally the fibrous tissue undergoes ossification.
No reliable therapy has emerged.